Sue Johnston, who plays Gloria Price in the ITV soap, Coronation Street, is leaving to work on other shows.
She will film her last scenes at Christmas, but show bosses are leaving open the possibility of a return.
The actress, 69, first appeared as Gloria, the interfering mother of Rovers landlady Stella Price (Michelle Collins), in September last year.
A spokeswoman for the show said: “Sue will be on screen until early spring 2014 when Gloria will leave Weatherfield for the time being.”
Sue shot to fame as Sheila Grant in Channel 4 soap Brookside and previously appeared in Coronation Street in a minor role as bookie’s wife Mrs Chadwick, in 1982.